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Article

Assembly-dependent Structure Formation Shapes Human Interleukin-23 versus Interleukin-12 Secretion.

Journal of molecular biology - 1 Dec 2023

Aschenbrenner Isabel, Siebenmorgen Till, Lopez Abraham, Parr Marina, Ruckgaber Philipp, Kerle Anna, Rührnößl Florian, Catici Dragana, Haslbeck Martin, Frishman Dmitrij, Sattler Michael, Zacharias Martin, Feige Matthias J

Abstract excerpt

Interleukin 12 (IL-12) family cytokines connect the innate and adaptive branches of the immune system and regulate immune responses. A unique characteristic of this family is that each member is anα:βheterodimer. For human αsubunits it has been shown that they depend on theirβsubunit for structure formation and secretion from cells. Since subunits are shared within the family and IL-12 as well as IL-23 use the...

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PMID: 37805067
DOI: 10.1016/j.jmb.2023.168300

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