Genes of the Escherichia coli pur regulon are negatively controlled by a repressor-operator interaction.

doi:10.1128/jb.172.8.4555-4562.1990

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Article

Genes of the Escherichia coli pur regulon are negatively controlled by a repressor-operator interaction.

Journal of bacteriology - 1 Aug 1990

He B, Shiau A, Choi K Y, Zalkin H, Smith J M

Abstract excerpt

Fusions of lacZ were constructed to genes in each of the loci involved in de novo synthesis of IMP. The expression of each pur-lacZ fusion was determined in isogenic purR and purR+ strains. These measurements indicated 5- to 17-fold coregulation of genes purF, purHD, purC, purMN, purL, and purEK and thus confirm the existence of a pur regulon. Gene purB, which encodes an enzyme involved in synthesis of IMP and in...

Topics

Base Sequence
Binding Sites
DNA, Bacterial
Deoxyribonuclease I
Escherichia coli
Gene Expression Regulation, Bacterial
Genes, Bacterial
Genes, Regulator
Genotype
Inosine Monophosphate
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Nucleotide Mapping

Operon

Purine Nucleotides

Repressor Proteins

Transcription Factors

Source

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Identifiers

PMID: 2198266
DOI: 10.1128/jb.172.8.4555-4562.1990
PMCID: PMC213288

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2198266-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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