Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of hypoxanthine and guanine as the co-repressors for the purine regulon genes of Escherichia coli.

Molecular microbiology - 1 Dec 1990

Meng L M, Nygaard P

Abstract excerpt

Addition of purine compounds to the growth medium of Escherichia coli and Salmonella typhimurium causes repressed synthesis of the purine biosynthetic enzymes. The repression is mediated through a regulatory protein, PurR. To identify the co-repressor(s) of PurR, two approaches were used: (i) mut...

Topics

Bacterial Proteins
Escherichia coli
Escherichia coli Proteins
Gene Expression Regulation, Bacterial
Genes, Bacterial
Guanine
Hypoxanthines
Mutation
Purines
Repressor Proteins
Salmonella typhimurium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 2089227
DOI: 10.1111/j.1365-2958.1990.tb00580.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2089227-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of hypoxanthine and guanine as the co-repressors for the purine regulon genes of Escherichia coli.PMID 2089227Read ↗

Autoregulation of PurR repressor synthesis and involvement of purR in the regulation of purB, purC, purL, purMN and guaBA expression in Escherichia coli.Semantic proximity Read ↗

Regulation of the Escherichia coli glyA gene by the purR gene product.Semantic proximity Read ↗

In vivo effect of mutations at the PRPP binding site of the Bacillus subtilis purine repressor.Semantic proximity Read ↗

Regulation of Escherichia coli pyrC by the purine regulon repressor protein.Semantic proximity Read ↗

Definition of a second Bacillus subtilis pur regulon comprising the pur and xpt-pbuX operons plus pbuG, nupG (yxjA), and pbuE (ydhL).Semantic proximity Read ↗

[Regulation of purine biosynthetic genes expression in Salmonella typhimurium. II. Isolation and characterization of Oc mutants].Semantic proximity Read ↗

Purine and pyrimidine-specific repression of the Escherichia coli carAB operon are functionally and structurally coupled.Semantic proximity Read ↗

Study of adaptive mutations in Salmonella typhimurium by using a super-repressing mutant of a trans regulatory gene purR.Semantic proximity Read ↗

Genes of the Escherichia coli pur regulon are negatively controlled by a repressor-operator interaction.Semantic proximity Read ↗

The nucleotide messenger (p)ppGpp is a co-repressor of the purine synthesis transcription regulator PurR in FirmicutesSemantic proximity Read ↗

[Studies of gene regulation of de novo biosynthetic pathway of purine in Salmonella typhimurium. X. Isolation of purR(am) mutants and preliminary studies of amino acid substitution].Semantic proximity Read ↗

Mutations in the Bacillus subtilis purine repressor that perturb PRPP effector function in vitro and in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.