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Article

Mutations in the Bacillus subtilis purine repressor that perturb PRPP effector function in vitro and in vivo.

Current microbiology - 1 Jul 2000

Weng M, Zalkin H

Abstract excerpt

The Bacillus subtilis pur operon repressor (PurR) has a PRPP (5-phosphoribosyl 1-pyrophosphate) binding motif at residues 199-211. Two PurR PRPP binding region mutations (D203A and D204A) were constructed, and the effects on binding of repressor to the pur operon control site in vitro and on regulation of pur operon expression in vivo were investigated. PRPP significantly inhibited the binding of wild-type but...

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PMID: 10919400
DOI: 10.1007/s002840010091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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