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Article

In vivo effect of mutations at the PRPP binding site of the Bacillus subtilis purine repressor.

Journal of bacteriology - 1 Nov 2003

Rappu Pekka, Pullinen Terhi, Mäntsälä Pekka

Abstract excerpt

The Bacillus subtilis PurR mediates adenine repression and guanosine induction of purA. PRPP inhibits binding of PurR to DNA in vitro. Mutations in the PRPP binding motif of PurR caused strong repression regardless of purine exclusions or additions, establishing the role of PRPP as regulator of PurR.

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Identifiers

PMID: 14594850
DOI: 10.1128/JB.185.22.6728-6731.2003
PMCID: PMC262106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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In vivo effect of mutations at the PRPP binding site of the Bacillus subtilis purine repressor.PMID 14594850Read ↗

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