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Article

Role of the purine repressor hinge sequence in repressor function.

Journal of bacteriology - 1 Mar 1994

Choi K Y, Zalkin H

Abstract excerpt

A protease-hypersensitive hinge sequence in Escherichia coli purine repressor (PurR) connects an N-terminal DNA-binding domain with a contiguous corepressor-binding domain. Binding of one molecule of dimeric repressor to operator DNA protects the hinge against proteolytic cleavage. Mutations in the hinge region impair repressor function in vivo. Several nonfunctional hinge mutants were defective in low-affinity...

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Identifiers

PMID: 8132474
DOI: 10.1128/jb.176.6.1767-1772.1994
PMCID: PMC205267

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