Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion.

Cell stem cell - 4 Oct 2011

Luis Tiago C, Naber Brigitta A E, Roozen Paul P C, Brugman Martijn H, de Haas Edwin F E, Ghazvini Mehrnaz, Fibbe Willem E, van Dongen Jacques J M, Fodde Riccardo, Staal Frank J T

Abstract excerpt

Canonical Wnt signaling has been implicated in the regulation of hematopoiesis. By employing a Wnt-reporter mouse, we observed that Wnt signaling is differentially activated during hematopoiesis, suggesting an important regulatory role for specific Wnt signaling levels. To investigate whether canonical Wnt signaling regulates hematopoiesis in a dosage-dependent fashion, we analyzed the effect of different...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clone Cells
Share to Gene Dosage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Targeting

Share to Hematopoiesis

Share to Hematopoietic System

Share to Myeloid Cells

Share to T-Lymphocytes

Share to Wnt Signaling Pathway

Source

Identifiers

PMID: 21982234
DOI: 10.1016/j.stem.2011.07.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion.PMID 21982234Read ↗

APC dosage effects in tumorigenesis and stem cell differentiation.Semantic proximity Read ↗

High Levels of Canonical Wnt Signaling Lead to Loss of Stemness and Increased Differentiation in Hematopoietic Stem Cells.Semantic proximity Read ↗

Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling.Semantic proximity Read ↗

The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS.Semantic proximity Read ↗

Wnt signalling in the mouse intestine.Semantic proximity Read ↗

Tissue-Specific Effects of Reduced β-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium.Semantic proximity Read ↗

APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development.Semantic proximity Read ↗

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.Semantic proximity Read ↗

A genetic study of the role of the Wnt/beta-catenin signalling in Paneth cell differentiation.Semantic proximity Read ↗

B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver.Semantic proximity Read ↗

Haploinsufficiency of Apc leads to ineffective hematopoiesisSemantic proximity Read ↗

Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.