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Article

The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS.

Blood - 29 Apr 2010

Lane Steven W, Sykes Stephen M, Al-Shahrour Fatima, Shterental Sebastian, Paktinat Mahnaz, Lo Celso Cristina, Jesneck Jonathan L, Ebert Benjamin L, Williams David A, Gilliland D Gary

Abstract excerpt

Apc, a negative regulator of the canonical Wnt signaling pathway, is a bona-fide tumor suppressor whose loss of function results in intestinal polyposis. APC is located in a commonly deleted region on human chromosome 5q, associated with myelodysplastic syndrome (MDS), suggesting that haploinsuff...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20197553
DOI: 10.1182/blood-2009-11-251728
PMCID: PMC2867262

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20197553-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS.PMID 20197553Read ↗

High Levels of Canonical Wnt Signaling Lead to Loss of Stemness and Increased Differentiation in Hematopoietic Stem Cells.Semantic proximity Read ↗

Deletion of the WNT Target and Cancer Stem Cell Marker CD44 in Apc(Min/+) Mice Attenuates Intestinal TumorigenesisSemantic proximity Read ↗

Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation.Semantic proximity Read ↗

Intestinal adenomas can develop with a stable karyotype and stable microsatellitesSemantic proximity Read ↗

Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion.Semantic proximity Read ↗

Haploinsufficiency of Apc leads to ineffective hematopoiesisSemantic proximity Read ↗

Complete deletion of Apc results in severe polyposis in mice.Semantic proximity Read ↗

Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling.Semantic proximity Read ↗

Loss of heterozygosity in spontaneous and x-ray-induced intestinal tumors arising in F1 hybridMin mice: Evidence for sequential loss ofApc+ andDpc4 in tumor developmentSemantic proximity Read ↗

PWD/Ph-Encoded Genetic Variants Modulate the Cellular Wnt/β-Catenin Response to Suppress Apc Min-Triggered Intestinal Tumor Formation.Semantic proximity Read ↗

Wnt signalling in the mouse intestine.Semantic proximity Read ↗

Severe polyposis in Apc1322Tmice is associated with submaximal Wnt signalling and increased expression of the stem cell markerLgr5Semantic proximity Read ↗

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