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Article

Gene dose effect of NAT2 variants on the pharmacokinetics of isoniazid and acetylisoniazid in healthy Chinese subjects.

Drug metabolism and drug interactions - 1 Jan 2011

Bing Chen, Xiaomeia Cao, Jinhenga Li

Abstract excerpt

BACKGROUND: The aim of this study was to elucidate the gene dose effect of NAT2 and the effect on the pharmacokinetics of isoniazid (INH) and its metabolites acetylisoniazid (AcINH) in Chinese subjects. METHODS: A total of 24 healthy Chinese subjects, consisting of eight homozygous wild types (wt/wt), eight heterozygous mutants (m/wt) and eight homozygous mutants (m/m) for NAT2, were enrolled in the study. The...

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Identifiers

PMID: 21980963
DOI: 10.1515/DMDI.2011.016

Genes

NAT2

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