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Article

Loss of p53 Ser18 and Atm results in embryonic lethality without cooperation in tumorigenesis.

PloS one - 1 Jan 2011

Armata Heather L, Shroff Punita, Garlick David E, Penta Krista, Tapper Andrew R, Sluss Hayla K

Abstract excerpt

Phosphorylation at murine Serine 18 (human Serine 15) is a critical regulatory process for the tumor suppressor function of p53. p53Ser18 residue is a substrate for ataxia-telangiectasia mutated (ATM) and ATM-related (ATR) protein kinases. Studies of mice with a germ-line mutation that replaces Ser18 with Ala (p53(S18A) mice) have demonstrated that loss of phosphorylation of p53Ser18 leads to the development of...

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Identifiers

PMID: 21980358
DOI: 10.1371/journal.pone.0024813
PMCID: PMC3181255

Genes

ATM
ATR

Variants

Provenance

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