Article
Impaired skin and mammary gland development and increased gamma-irradiation-induced tumorigenesis in mice carrying a mutation of S1152-ATM phosphorylation site in Brca1.
Cancer research - 15 Dec 2009
Kim Sang Soo, Cao Liu, Baek Hye Jung, Lim Sung-Chul, Li Cuiling, Wang Rui-Hong, Xu Xiaoling, Cho Kwan Ho, Deng Chu-Xia
Abstract excerpt
The tumor suppressor BRCA1 interacts with many proteins and undergoes multiple modifications on DNA damage. ATM, a key molecule of the DNA damage response, phosphorylates S1189 of BRCA1 after gamma-irradiation. S1189 of BRCA1 is known as a unique ATM phosphorylation site in BRCA1 exon 11. To study the functions of ATM-dependent phosphorylation of BRCA1-S1189, we generated a mouse model carrying a mutation of...
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