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Article

Hypoxia inducible factor-1α gene polymorphisms in Korean patients with pre-eclampsia.

Journal of endocrinological investigation - 1 Jul 2012

Kim S Y, Park S Y, Lim J H, Lee B Y, Yang J H, Ryu H M

Abstract excerpt

BACKGROUND: Placental hypoxia has been implicated in the pathogenesis of pre-eclampsia. Hypoxia inducible factor-1α (HIF-1α) is activated by low oxygen tension and is a key regulator of genes involved in the cellular responses to hypoxia. AIM: We determined whether maternal blood c.1722C>T (Pro582Ser) and c.1790G>A (Ala588Thr) polymorphisms in exon 12 of the HIF-1α gene are associated with pre-eclampsia. SUBJECTS...

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PMID: 21979130
DOI: 10.3275/8009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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