Article
An association study between hypoxia inducible factor-1alpha (HIF-1α) polymorphisms and osteonecrosis.
PloS one - 1 Jan 2013
Chachami Georgia, Kalousi Alkmini, Papatheodorou Loukia, Lyberopoulou Aggeliki, Nasikas Vasileios, Tanimoto Keiji, Simos George, Malizos Konstantinos N, Georgatsou Eleni
Abstract excerpt
Bone hypoxia resulting from impaired blood flow is the final pathway for the development of osteonecrosis (ON). The aim of this study was to evaluate if HIF-1α, the major transcription factor triggered by hypoxia, is genetically implicated in susceptibility to ON. For this we analyzed frequencies of three known HIF-1α polymorphisms: one in exon 2 (C111A) and two in exon 12 (C1772T and G1790A) and their...
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