Article
Rare variant of hypoxia-inducible factor-1alpha (HIF-1A) and breast cancer risk in Korean women.
Clinica chimica acta; international journal of clinical chemistry - 1 Mar 2008
Lee Ji-Young, Choi Ji-Yeob, Lee Kyoung-Mu, Park Sue Kyung, Han So-Hee, Noh Dong-Young, Ahn Sei-Hyun, Kim Dong-Hyun, Hong Yun-Chul, Ha Eunhee, Yoo Keun-Young, Ambrosone Christine B, Kang Daehee
Abstract excerpt
BACKGROUND: Hypoxia inducible factor 1 alpha (HIF-1A) is activated by low oxygen condition tension, a key regulator of the gene involved in the cellular response to hypoxia. Tumors exhibiting extensive hypoxia are more aggressive than tumors oxygenized better. METHODS: To evaluate the potential role of the polymorphisms of HIF-1A in the etiology of breast cancer, histologically confirmed incident breast cancer...
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