Article
An investigation of relationships between hypoxia-inducible factor-1 alpha gene polymorphisms and ovarian, cervical and endometrial cancers.
Cancer detection and prevention - 1 Jan 2007
Konac Ece, Onen H Ilke, Metindir Jale, Alp Ebru, Biri Aydan Asyali, Ekmekci Abdullah
Abstract excerpt
BACKGROUND: DNA sequence variations in HIF-1 alpha gene might yield changes both in the production outcomes and in the activities of the gene. Overexpression of the HIF-1 alpha subunit, resulting from intratumoral hypoxia and genetic alterations, has been demonstrated in common human cancers and is correlated with tumor angiogenesis and patient mortality. In this study, we aimed to determine how the three single...
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