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Article

No association of hypoxia inducible factor-1α gene polymorphisms with breast cancer in North-West Indians.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2014

Sharma Sarika, Kapahi Ruhi, Sambyal Vasudha, Guleria Kamlesh, Manjari Mridu, Sudan Meena, Uppal Manjit Singh, Singh Neeti Rajan

Abstract excerpt

BACKGROUND: Hypoxia inducible factor-1 alpha (HIF-1α) is the key regulator of cellular responses to hypoxia and plays a central role in tumour growth. Presence of Single nucleotide polymorphisms (SNPs) in the critical regulatory domains of HIF-1α may result in the overexpression of the protein and subsequent changes in the expression of the downstream target genes. The aim of study was to investigate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25520138
DOI: 10.7314/apjcp.2014.15.22.9973

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