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Article

The association of the placental Hypoxia-inducible factor1-α polymorphisms and HIF1-α mRNA expression with preeclampsia.

Placenta - 1 Jul 2018

Harati-Sadegh Mahdiyeh, Kohan Leila, Teimoori Batool, Mehrabani Mehrnaz, Salimi Saeedeh

Abstract excerpt

INTRODUCTION: Evidence has confirmed that placental/fetal hypoxia plays a key role in both endothelial cell dysfunction and PE pathogenesis. The aim of the present study was to investigate whether maternal/placental hypoxia-inducible factor1-α (HIF1-α) C1772T (rs11549465) and/or G1790A (rs11549467) polymorphisms and HIF1-α mRNA expression are associated with PE development. METHODS: The blood samples of 203 PE...

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PMID: 29941171
DOI: 10.1016/j.placenta.2018.05.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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