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Article

Molecular Evaluation of HIF-1α Gene Variation and Determination of Its Frequency and Association with Breast Cancer Susceptibility in Saudi Arabia.

Endocrine, metabolic & immune disorders drug targets - 1 Jan 2021

Mir Rashid, Abu-Duhier Faisel M, Albalawi Ibrahim A

Abstract excerpt

AIM: Hypoxia-inducible factor 1 (HIF-1α) is responsible in regulating oxygen homeostasis in tissues and is a central effector of the hypoxic response besides its protein overexpression has been shown to have prognostic relevance in several cancers including breast cancer. Several reports indicated that HIF-1α gene variation C1772T (Pro582Ser) is associated with increased breast susceptibility but results remained...

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PMID: 32914726
DOI: 10.2174/1871530320666200910105214

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