Article
Characterization of the gating brake in the I-II loop of Ca(v)3.2 T-type Ca(2+) channels.
The Journal of biological chemistry - 28 Mar 2008
Arias-Olguín Imilla I, Vitko Iuliia, Fortuna Michal, Baumgart Joel P, Sokolova Svetlana, Shumilin Igor A, Van Deusen Amy, Soriano-García Manuel, Gomora Juan C, Perez-Reyes Edward
Abstract excerpt
Mutations in the I-II loop of Ca(v)3.2 channels were discovered in patients with childhood absence epilepsy. All of these mutations increased the surface expression of the channel, whereas some mutations, and in particular C456S, altered the biophysical properties of channels. Deletions around C456S were found to produce channels that opened at even more negative potentials than control, suggesting the presence...
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