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Article

Asymmetric configurations and N-terminal rearrangements in connexin26 gap junction channels.

Journal of molecular biology - 21 Jan 2011

Oshima Atsunori, Tani Kazutoshi, Toloue Masoud M, Hiroaki Yoko, Smock Amy, Inukai Sayaka, Cone Angela, Nicholson Bruce J, Sosinsky Gina E, Fujiyoshi Yoshinori

Abstract excerpt

Gap junction channels are unique in that they possess multiple mechanisms for channel closure, several of which involve the N terminus as a key component in gating, and possibly assembly. Here, we present electron crystallographic structures of a mutant human connexin26 (Cx26M34A) and an N-terminal deletion of this mutant (Cx26M34Adel2-7) at 6-Å and 10-Å resolutions, respectively. The three-dimensional map of...

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Identifiers

PMID: 21094651
DOI: 10.1016/j.jmb.2010.10.032
PMCID: PMC3026138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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