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Article

Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinoma.

BMC gastroenterology - 6 Oct 2011

van de Winkel Anouk, Menke Vivianda, Capello Astrid, Moons Leon M G, Pot Raymond G J, van Dekken Herman, Siersema Peter D, Kusters Johannes G, van der Laan Luc J W, Kuipers Ernst J

Abstract excerpt

BACKGROUND: The continuous exposure of esophageal epithelium to refluxate may induce ectopic expression of bile-responsive genes and contribute to the development of Barrett's esophagus (BE) and esophageal adenocarcinoma. In normal physiology of the gut and liver, the nuclear receptor Pregnane × Receptor (PXR) is an important factor in the detoxification of xenobiotics and bile acid homeostasis. This study aimed...

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Identifiers

PMID: 21977915
DOI: 10.1186/1471-230X-11-108
PMCID: PMC3204292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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