Article
Impact of global Fxr deficiency on experimental acute pancreatitis and genetic variation in the FXR locus in human acute pancreatitis.
PloS one - 1 Jan 2014
Nijmeijer Rian M, Schaap Frank G, Smits Alexander J J, Kremer Andreas E, Akkermans Louis M A, Kroese Alfons B A, Rijkers Ger T, Schipper Marguerite E I, Verheem André, Wijmenga Cisca, Gooszen Hein G, van Erpecum Karel J
Abstract excerpt
BACKGROUND: Infectious complications often occur in acute pancreatitis, related to impaired intestinal barrier function, with prolonged disease course and even mortality as a result. The bile salt nuclear receptor farnesoid X receptor (FXR), which is expressed in the ileum, liver and other organs including the pancreas, exhibits anti-inflammatory effects by inhibiting NF-κB activation and is implicated in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.