Article
A role for metallothionein and zinc in spontaneous mutagenesis.
Cancer research - 15 Oct 1994
Goncharova E I, Rossman T G
Abstract excerpt
G12, a transgenic Chinese hamster V79 cell derivative which contains a single copy of the Escherichia coli gpt gene as a target for mutagenesis, has little constitutive metallothionein (MT) expression. It was transfected with a vector containing the mouse MT-I gene, and MT-I-overproducing lines were isolated. MT-I transfectants had lower spontaneous mutation frequencies compared with the G12 parental cell line....
Topics
- Animals
- Cadmium
- Cell Line
- Chlorides
- Cricetinae
- Cricetulus
- Drug Resistance
- Ethyl Methanesulfonate
- Metallothionein
- Methylnitronitrosoguanidine
- Mutagenicity Tests
- Mutation