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Article

Impaired branched chain amino acid metabolism alters feeding behavior and increases orexigenic neuropeptide expression in the hypothalamus.

The Journal of endocrinology - 1 Jan 2012

Purpera Megan N, Shen Li, Taghavi Marzieh, Münzberg Heike, Martin Roy J, Hutson Susan M, Morrison Christopher D

Abstract excerpt

Elevation of dietary or brain leucine appears to suppress food intake via a mechanism involving mechanistic target of rapamycin, AMPK, and/or branched chain amino acid (BCAA) metabolism. Mice bearing a deletion of mitochondrial branched chain aminotransferase (BCATm), which is expressed in peripheral tissues (muscle) and brain glia, exhibit marked increases in circulating BCAAs. Here, we test whether this...

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Identifiers

PMID: 21969404
DOI: 10.1530/JOE-11-0270
PMCID: PMC3350378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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