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Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity

25 Oct 2021

Abstract excerpt

The gut microbiome has emerged as a key regulator of obesity; however, its role in brown adipose tissue (BAT) metabolism and association with obesity remain to be elucidated. We found that the levels of circulating branched-chain amino acids (BCAA) and their cognate α-ketoacids (BCKA) were significantly correlated with the body weight in humans and mice and that BCAA catabolic defects in BAT were associated with...

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PMID: 34805797
DOI: 10.1016/j.isci.2021.103342

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