Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alcohol-induced IGF-I resistance is ameliorated in mice deficient for mitochondrial branched-chain aminotransferase.

The Journal of nutrition - 1 May 2010

Lang Charles H, Lynch Christopher J, Vary Thomas C

Abstract excerpt

Acute alcohol intoxication decreases skeletal muscle protein synthesis by impairing mammalian target of rapamycin (mTOR). In 2 studies, we determined whether inhibition of branched-chain amino acid (BCAA) catabolism ameliorates the inhibitory effect of alcohol on muscle protein synthesis by raising the plasma BCAA concentrations and/or by improving the anabolic response to insulin-like growth factor (IGF)-I. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcoholic Intoxication
Share to Amino Acids, Branched-Chain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eukaryotic Initiation Factor-4E

Share to Eukaryotic Initiation Factor-4G

Share to Insulin-Like Growth Factor I

Share to Ribosomal Protein S6 Kinases, 70-kDa

Share to TOR Serine-Threonine Kinases

Share to Transaminases

Source

Open in PubMed Open full text

Identifiers

PMID: 20237068
DOI: 10.3945/jn.109.120501
PMCID: PMC2855262

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alcohol-induced IGF-I resistance is ameliorated in mice deficient for mitochondrial branched-chain aminotransferase.PMID 20237068Read ↗

Impaired branched chain amino acid metabolism alters feeding behavior and increases orexigenic neuropeptide expression in the hypothalamus.Semantic proximity Read ↗

Alcoholic Cardiomyopathy: Disrupted Protein Balance and Impaired Cardiomyocyte ContractilitySemantic proximity Read ↗

Hepatic autophagy contributes to the metabolic response to dietary protein restriction.Semantic proximity Read ↗

The role of BCAA metabolism in metabolic health and diseaseSemantic proximity Read ↗

Additive regulation of hepatic gene expression by dwarfism and caloric restrictionSemantic proximity Read ↗

Branched-Chain Amino Acid Metabolism is Regulated by ERRα in Primary Human Myotubes and is Further Impaired by Glucose Loading in Type 2 DiabetesSemantic proximity Read ↗

Growth hormone abolishes beneficial effects of calorie restriction in long-lived Ames dwarf mice.Semantic proximity Read ↗

Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span.Semantic proximity Read ↗

Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscleSemantic proximity Read ↗

Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO mice.Semantic proximity Read ↗

Dynamic MTORC1-TFEB feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply.Semantic proximity Read ↗

Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.