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Article

No effect of folic acid supplementation on global DNA methylation in men and women with moderately elevated homocysteine.

PloS one - 1 Jan 2011

Jung Audrey Y, Smulders Yvo, Verhoef Petra, Kok Frans J, Blom Henk, Kok Robert M, Kampman Ellen, Durga Jane

Abstract excerpt

A global loss of cytosine methylation in DNA has been implicated in a wide range of diseases. There is growing evidence that modifications in DNA methylation can be brought about by altering the intake of methyl donors such as folate. We examined whether long-term daily supplementation with 0.8 mg of folic acid would increase global DNA methylation compared with placebo in individuals with elevated plasma...

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Identifiers

PMID: 21966393
DOI: 10.1371/journal.pone.0024976
PMCID: PMC3179474

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MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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No effect of folic acid supplementation on global DNA methylation in men and women with moderately elevated homocysteine.PMID 21966393Read ↗

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