Impact of folic acid supplementation on the epigenetic profile in healthy unfortified individuals – a randomized intervention trial

Abstract excerpt

Folate is an essential mediator in one-carbon metabolism, which provides methyl groups for DNA synthesis and methylation.The availability of active methyl groups can be influenced by the uptake of folic acid.We conducted a randomized intervention trial to test the influence of folic acid supplementation on DNA methylation in an unfortified population in Germany.A total of 16 healthy male volunteers (age range...

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