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Article

Genomic DNA methylation changes in response to folic acid supplementation in a population-based intervention study among women of reproductive age.

PloS one - 1 Jan 2011

Crider Krista S, Quinlivan Eoin P, Berry Robert J, Hao Ling, Li Zhu, Maneval David, Yang Thomas P, Rasmussen Sonja A, Yang Quanhe, Zhu Jiang-Hui, Hu Dale J, Bailey Lynn B

Abstract excerpt

Folate is a source of one-carbons necessary for DNA methylation, a critical epigenetic modification necessary for genomic structure and function. The use of supplemental folic acid is widespread however; the potential influence on DNA methylation is unclear. We measured global DNA methylation using DNA extracted from samples from a population-based, double-blind randomized trial of folic acid supplementation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22163281
DOI: 10.1371/journal.pone.0028144
PMCID: PMC3233549

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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