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Article

Effect of 1 year B and D vitamin supplementation on LINE-1 repetitive element methylation in older subjects

1 Jan 2013

Abstract excerpt

BACKGROUND: Disturbed DNA methylation is causally related to chronic diseases like cancer and atherosclerosis. B vitamins are cofactors required for methyl group synthesis and may therefore affect DNA methylation. Vitamin D has epigenetic effects. We tested if B and D vitamin supplementation has an effect on genomic long interspersed nuclear element-1 (LINE-1) methylation and the metabolites S-adenosylmethionine...

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PMID: 23314556
DOI: 10.1515/cclm-2012-0624

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