Article
Population genomics and transcriptional consequences of regulatory motif variation in globally diverse Saccharomyces cerevisiae strains.
Molecular biology and evolution - 1 Jul 2013
Connelly Caitlin F, Skelly Daniel A, Dunham Maitreya J, Akey Joshua M
Abstract excerpt
Noncoding genetic variation is known to significantly influence gene expression levels in a growing number of specific cases; however, the patterns of genome-wide noncoding variation present within populations, the evolutionary forces acting on noncoding variants, and the relative effects of regulatory polymorphisms on transcript abundance are not well characterized. Here, we address these questions by analyzing...
Topics
- Binding Sites
- DNA-Binding Proteins
- Evolution, Molecular
- Gene Expression Regulation, Fungal
- Genetic Variation
- Genome, Fungal
- Metagenomics
- Nucleotide Motifs
- Phylogeny
- Promoter Regions, Genetic
- Regulatory Sequences, Nucleic Acid
- Saccharomyces cerevisiae
- Transcriptional Activation