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Article

Systematic identification and annotation of multiple-variant compound effects at transcription factor binding sites in human genome.

Journal of genetics and genomics = Yi chuan xue bao - 20 Jul 2018

Cheng Si-Jin, Jiang Shuai, Shi Fang-Yuan, Ding Yang, Gao Ge

Abstract excerpt

Understanding the functional effects of genetic variants is crucial in modern genomics and genetics. Transcription factor binding sites (TFBSs) are one of the most important cis-regulatory elements. While multiple tools have been developed to assess functional effects of genetic variants at TFBSs, they usually assume that each variant works in isolation and neglect the potential "interference" among multiple...

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PMID: 30054217
DOI: 10.1016/j.jgg.2018.05.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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