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Article

Discovery of novel transcription factor binding sites by statistical overrepresentation.

Nucleic acids research - 15 Dec 2002

Sinha Saurabh, Tompa Martin

Abstract excerpt

Understanding the complex and varied mechanisms that regulate gene expression is an important and challenging problem. A fundamental sub-problem is to identify DNA binding sites for unknown regulatory factors, given a collection of genes believed to be co-regulated. We discuss a computational method that identifies good candidates for such binding sites. Unlike local search techniques such as expectation...

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Identifiers

PMID: 12490723
DOI: 10.1093/nar/gkf669
PMCID: PMC140044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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