Article
A Functional Interleukin-18 Haplotype Predicts Depression and Anxiety through Increased Threat-Related Amygdala Reactivity in Women but Not Men.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2017
Swartz Johnna R, Prather Aric A, Di Iorio Christina R, Bogdan Ryan, Hariri Ahmad R
Abstract excerpt
Common functional polymorphisms in the gene encoding interleukin-18 (IL18), a cytokine belonging to the IL-1 superfamily that can induce synthesis of several other cytokines, have been associated with major depressive episodes following the experience of stressful life events. The neural mechanisms underlying these associations remain unexamined. Here we use an imaging genetics strategy to examine the effects of...
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