Association of genetic variants in the promoter region of genes encoding p22phox (CYBA) and glutamate cysteine ligase catalytic subunit (GCLC) and renal disease in patients with type 1 diabetes mellitus.

doi:10.1186/1471-2350-12-129

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Association of genetic variants in the promoter region of genes encoding p22phox (CYBA) and glutamate cysteine ligase catalytic subunit (GCLC) and renal disease in patients with type 1 diabetes mellitus.

BMC medical genetics - 30 Sept 2011

Vieira Suzana M, Monteiro Maria B, Marques Tatiana, Luna Ana M, Fortes Maria A, Nery Márcia, Queiroz Márcia, Dib Sérgio A, Vendramini Márcio F, Azevedo Mirela J, Canani Luis H, Parisi Maria C, Pavin Elizabeth J, Giannella-Neto Daniel, Corrêa-Giannella Maria L

Abstract excerpt

BACKGROUND: Oxidative stress is recognized as a major pathogenic factor of cellular damage caused by hyperglycemia. NOX/NADPH oxidases generate reactive oxygen species and NOX1, NOX2 and NOX4 isoforms are expressed in kidney and require association with subunit p22phox (encoded by the CYBA gene). Increased expression of p22phox was described in animal models of diabetic nephropathy. In the opposite direction,...

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Identifiers

PMID: 21962117
DOI: 10.1186/1471-2350-12-129
PMCID: PMC3206419

Genes

CYBA
GCLC
GPX3
NOX1
NOX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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