Article
Relationship between common functional polymorphisms of the p22phox gene (-930A > G and +242C > T) and nephropathy as a result of Type 2 diabetes in a Chinese population.
Diabetic medicine : a journal of the British Diabetic Association - 1 Sept 2006
Lim S C, Goh S K, Lai Y R, Tee W W, Koh A, Xu X H, Wu Y S, Yap E, Subramaniam T, Sum C F
Abstract excerpt
OBJECTIVE: Genetic determinants are important in diabetic nephropathy (DN). Oxidative stress has also emerged as an important pathogenic factor in DN and vascular NADH oxidase is a major source of reactive oxygen species (ROS). Previous small studies reported a strong but contradictory association between functional genetic variation of p22(phox), an important subcomponent of NADH oxidase, and DN. We investigated...
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