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Article

Sex-specific associations of variants in regulatory regions of NADPH oxidase-2 (CYBB) and glutathione peroxidase 4 (GPX4) genes with kidney disease in type 1 diabetes.

Free radical research - 1 Oct 2013

Monteiro M B, Patente T A, Mohammedi K, Queiroz M S, Azevedo M J, Canani L H, Parisi M C, Marre M, Velho G, Corrêa-Giannella M L

Abstract excerpt

Oxidative stress is involved in the pathophysiology of diabetic nephropathy. The superoxide-generating nicotinamide adenine dinucleotide phosphate-oxidase 2 (NOX2, encoded by the CYBB gene) and the antioxidant enzyme glutathione peroxidase 4 (GPX4) play opposing roles in the balance of cellular redox status. In the present study, we investigated associations of single nucleotide polymorphisms (SNPs) in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23919599
DOI: 10.3109/10715762.2013.828347

Genes

CYBB
GPX4

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