Article
Catalase activity, allelic variations in the catalase gene and risk of kidney complications in patients with type 1 diabetes.
Diabetologia - 1 Dec 2013
Mohammedi Kamel, Patente Thiago A, Bellili-Muñoz Naïma, Driss Fathi, Monteiro Maria Beatriz, Roussel Ronan, Pavin Elizabeth J, Seta Nathalie, Fumeron Frédéric, Azevedo Mirela J, Canani Luis H, Hadjadj Samy, Marre Michel, Corrêa-Giannella Maria Lúcia, Velho Gilberto
Abstract excerpt
AIMS/HYPOTHESIS: Oxidative stress is involved in the pathogenesis of diabetic nephropathy. The antioxidant enzyme catalase plays a key role in redox regulation in the kidney. We investigated associations of catalase gene (CAT) polymorphisms and plasma catalase activity with diabetic nephropathy in type 1 diabetic patients. METHODS: We genotyped nine single nucleotide polymorphisms (SNPs) in the CAT region in...
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