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Article

Enhanced effects of isoflurane on the long QT syndrome 1-associated A341V mutant.

Anesthesiology - 1 Apr 2015

Mikuni Ikuomi, Torres Carlos G, Bakshi Tania, Tampo Akihito, Carlson Brian E, Bienengraeber Martin W, Kwok Wai-Meng

Abstract excerpt

BACKGROUND: The impact of volatile anesthetics on patients with inherited long QT syndrome (LQTS) is not well understood. This is further complicated by the different genotypes underlying LQTS. No studies have reported on the direct effects of volatile anesthetics on specific LQTS-associated mutations. We investigated the effects of isoflurane on a common LQTS type 1 mutation, A341V, with an unusually severe...

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Identifiers

PMID: 25585005
DOI: 10.1097/ALN.0000000000000583
PMCID: PMC4366337

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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