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Article

Molecular mechanism of allosteric modification of voltage-dependent sodium channels by local anesthetics.

The Journal of general physiology - 1 Nov 2010

Arcisio-Miranda Manoel, Muroi Yukiko, Chowdhury Sandipan, Chanda Baron

Abstract excerpt

The hallmark of many intracellular pore blockers such as tetra-alkylammonium compounds and local anesthetics is their ability to allosterically modify the movement of the voltage sensors in voltage-dependent ion channels. For instance, the voltage sensor of domain III is specifically stabilized i...

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Identifiers

PMID: 20937693
DOI: 10.1085/jgp.201010438
PMCID: PMC2964522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20937693-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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