Low incidence of point mutation at codon 12 of K-ras proto-oncogene in squamous cell carcinoma of the upper aerodigestive tract.

doi:10.1177/000348949110000716

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Article

Low incidence of point mutation at codon 12 of K-ras proto-oncogene in squamous cell carcinoma of the upper aerodigestive tract.

The Annals of otology, rhinology, and laryngology - 1 Jul 1991

Hirano T, Steele P E, Gluckman J L

Abstract excerpt

Forty-two cases of squamous cell carcinoma arising in the upper aerodigestive tract were examined to determine the incidence and type of point mutation in codon 12 of the c-K-ras gene by using the polymerase chain reaction and oligonucleotide hybridization techniques on DNA extracted from paraffin blocks. DNA sequencing, in addition, was performed in 4 cases. No point mutation was detected in codon 12 of c-K-ras...

Topics

Adult
Aged
Base Sequence
Carcinoma, Squamous Cell
Codon
DNA, Neoplasm
Female
Gene Expression Regulation
Humans
Laryngeal Neoplasms
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mouth Neoplasms

Mutation

Nucleic Acid Hybridization

Oligonucleotide Probes

Pharyngeal Neoplasms

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 2064275
DOI: 10.1177/000348949110000716

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2064275-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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