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Article

Alterations in epidermal biochemistry as a consequence of stage-specific genetic changes in skin carcinogenesis.

Environmental health perspectives - 1 Jun 1991

Yuspa S H, Kilkenny A, Cheng C, Roop D, Hennings H, Kruszewski F, Lee E, Strickland J, Greenhalgh D A

Abstract excerpt

The induction of cancer on mouse skin by initiation-promotion protocols occurs through stages in which a benign squamous papilloma is an obligate precursor of squamous cell carcinoma. Activation of the Ha-ras gene is sufficient to produce the papilloma phenotype, while additional genetic changes are required for malignant conversion. The introduction of Ha-ras into normal keratinocytes suppresses the expression...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 1773799
DOI: 10.1289/ehp.91933
PMCID: PMC1568044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Alterations in epidermal biochemistry as a consequence of stage-specific genetic changes in skin carcinogenesis.PMID 1773799Read ↗

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