Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alterations in epidermal biochemistry as a consequence of stage-specific genetic changes in skin carcinogenesis.

Environmental health perspectives - 1 Jun 1991

Yuspa S H, Kilkenny A, Cheng C, Roop D, Hennings H, Kruszewski F, Lee E, Strickland J, Greenhalgh D A

Abstract excerpt

The induction of cancer on mouse skin by initiation-promotion protocols occurs through stages in which a benign squamous papilloma is an obligate precursor of squamous cell carcinoma. Activation of the Ha-ras gene is sufficient to produce the papilloma phenotype, while additional genetic changes are required for malignant conversion. The introduction of Ha-ras into normal keratinocytes suppresses the expression...

Topics

Animals
Biomarkers, Tumor
Calcium
Carcinogens
Carcinoma, Squamous Cell
Cell Line, Transformed
Cell Transformation, Neoplastic
Cells, Cultured
Epidermis
Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, ras

Keratinocytes

Mice

Oncogene Protein p21(ras)

Oncogene Proteins v-fos

Papilloma

Phenotype

Retroviridae

Source

Open in PubMed Open full text

Identifiers

PMID: 1773799
DOI: 10.1289/ehp.91933
PMCID: PMC1568044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1773799-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alterations in epidermal biochemistry as a consequence of stage-specific genetic changes in skin carcinogenesis.PMID 1773799Read ↗

Analysis of phospholipid metabolism in murine keratinocytes transformed by the v-ras oncogene: relationship of phosphatidylinositol turnover and cytokine stimulation to the transformed phenotype.Semantic proximity Read ↗

Alterations in protein kinase C isozymes alpha and beta 2 in activated Ha-ras containing papillomas in the absence of an increase in diacylglycerol.Semantic proximity Read ↗

Alterations in the biology and biochemistry of keratinocytes induced by the ras oncogene.Semantic proximity Read ↗

Differences in the regulation of intracellular calcium in normal and neoplastic keratinocytes are not caused by ras gene mutations.Semantic proximity Read ↗

Signal Transduction Pathways Controlling the Switch Between Keratinocyte Growth and DifferentiationSemantic proximity Read ↗

Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo.Semantic proximity Read ↗

Topical retinoic acid reduces skin papilloma formation but resistant papillomas are at high risk for malignant conversion.Semantic proximity Read ↗

Vitamin D regulated keratinocyte differentiationSemantic proximity Read ↗

Aberrant in vitro expression of keratin K13 induced by Ca2+ and vitamin A acid in mouse epidermal cell lines.Semantic proximity Read ↗

Thapsigargin, a weak skin tumor promoter, alters the growth and differentiation of mouse keratinocytes in culture.Semantic proximity Read ↗

A PMLRARA transgene results in a retinoid-deficient phenotype associated with enhanced susceptibility to skin tumorigenesis.Semantic proximity Read ↗

Characterization of benzo[a]pyrene-initiated mouse skin papillomas for Ha-ras mutations and protein kinase C levels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.