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Article

Developmental changes in human liver CYP2D6 expression.

Drug metabolism and disposition: the biological fate of chemicals - 1 Aug 2008

Stevens Jeffrey C, Marsh Sandra A, Zaya Matthew J, Regina Karen J, Divakaran Karthika, Le Min, Hines Ronald N

Abstract excerpt

Within the human cytochrome P450 family, specific forms show developmental expression patterns that can affect drug clearance, efficacy, and safety. The objective of this study was to use dextromethorphan O-demethylase activity and quantitative Western blotting to identify CYP2D6 developmental expression patterns in a large (n = 222) and developmentally diverse set of pediatric liver samples. Immunodetectable...

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Source

Identifiers

PMID: 18474679
DOI: 10.1124/dmd.108.021873

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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