Article
Parkinson's disease, CYP2D6 polymorphism, and age.
Neurology - 22 May 2001
Payami H, Lee N, Zareparsi S, Gonzales McNeal M, Camicioli R, Bird T D, Sexton G, Gancher S, Kaye J, Calhoun D, Swanson P D, Nutt J
Abstract excerpt
OBJECTIVE: PD may be caused by genetic susceptibility to neurotoxins. CYP2D6 is a candidate gene for PD because it regulates drug and toxin metabolism, but association studies have been inconsistent. The aim of this study was to test if the CYP2D6*4 allele (poor metabolizer phenotype) is associated with earlier age at onset. METHODS: Five hundred seventy-six patients with PD and 247 subjects without PD were...
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