Article
P450 enzymes and Parkinson's disease: the story so far.
Movement disorders : official journal of the Movement Disorder Society - 1 Mar 1998
Riedl A G, Watts P M, Jenner P, Marsden C D
Abstract excerpt
Environmental or endogenous toxins may cause nigral cell death in Parkinson's disease (PD) as a result of genetic susceptibility conferred by altered expression of P450 enzymes. Attention over the last 10 years has focused on CYP2D6 polymorphisms and susceptibility to PD. This review summarizes r...
Topics
- Animals
- Cell Death
- Cytochrome P-450 CYP1A1
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- DNA Mutational Analysis
- Gene Expression Regulation, Enzymologic
- Genotype
- Humans
- Parkinson Disease
- Phenotype
- Polymorphism, Genetic
- Substantia Nigra