Article
P450 enzymes and Parkinson's disease: the story so far.
Movement disorders : official journal of the Movement Disorder Society - 1 Mar 1998
Riedl A G, Watts P M, Jenner P, Marsden C D
Abstract excerpt
Environmental or endogenous toxins may cause nigral cell death in Parkinson's disease (PD) as a result of genetic susceptibility conferred by altered expression of P450 enzymes. Attention over the last 10 years has focused on CYP2D6 polymorphisms and susceptibility to PD. This review summarizes reports arising from both phenotypic and genotypic studies involving CYP2D6 and PD. Phenotypic studies have failed to...
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