Article
Genotyping of CYP2D6 in Parkinson's disease.
Clinical chemistry and laboratory medicine - 1 Sept 2000
Stefanović M, Topić E, Ivanisević A M, Relja M, Korsić M
Abstract excerpt
Parkinson's disease is characterized by progressive degradation of dopaminergic neurons. Cytochrome P450 CYP2D6 enzyme is one of the most investigated and highly polymorphic isoforms, which metabolizes many drugs and is also involved in the metabolism of dopamine. Using allele-specific multiplex PCR, we genotyped 186 subjects for CYP2D6 *3, *4, *6, *7, and *8 alleles in order to estimate allelic, genotype and...
Topics
- Adult
- Alleles
- Cytochrome P-450 CYP2D6
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Parkinson Disease
- Phenotype
- Polymerase Chain Reaction
- Reference Values
- Risk