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Article

Genomic and phenotypic analysis of BRCA2 mutated breast cancers reveals co-occurring changes linked to progression.

Breast cancer research : BCR - 29 Sept 2011

Stefansson Olafur A, Jonasson Jon G, Olafsdottir Kristrun, Bjarnason Hordur, Th Johannsson Oskar, Bodvarsdottir Sigridur K, Valgeirsdottir Sigridur, Eyfjord Jorunn E

Abstract excerpt

BACKGROUND: Inherited mutations in the BRCA2 gene greatly increase the risk of developing breast cancer. Consistent with an important role for BRCA2 in error-free DNA repair, complex genomic changes are frequently observed in tumors derived from BRCA2 mutation carriers. Here, we explore the impact of DNA copy-number changes in BRCA2 tumors with respect to phenotype and clinical staging of the disease. METHODS:...

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Identifiers

PMID: 21958427
DOI: 10.1186/bcr3020
PMCID: PMC3262207

Genes

BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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