Article
Genomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and clinical characteristics.
Breast cancer research : BCR - 1 Jan 2010
Jönsson Göran, Staaf Johan, Vallon-Christersson Johan, Ringnér Markus, Holm Karolina, Hegardt Cecilia, Gunnarsson Haukur, Fagerholm Rainer, Strand Carina, Agnarsson Bjarni A, Kilpivaara Outi, Luts Lena, Heikkilä Päivi, Aittomäki Kristiina, Blomqvist Carl, Loman Niklas, Malmström Per, Olsson Håkan, Johannsson Oskar Th, Arason Adalgeir, Nevanlinna Heli, Barkardottir Rosa B, Borg Ake
Abstract excerpt
INTRODUCTION: Breast cancer is a profoundly heterogeneous disease with respect to biologic and clinical behavior. Gene-expression profiling has been used to dissect this complexity and to stratify tumors into intrinsic gene-expression subtypes, associated with distinct biology, patient outcome, and genomic alterations. Additionally, breast tumors occurring in individuals with germline BRCA1 or BRCA2 mutations...
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