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DNA Mismatch Repair Proteins Are Required for Efficient Herpes Simplex Virus 1 Replication

29 Sept 2011

Abstract excerpt

Herpes simplex virus 1 (HSV-1) is a double-stranded DNA virus that replicates in the nucleus of its human host cell and is known to interact with many cellular DNA repair proteins. In this study, we examined the role of cellular mismatch repair (MMR) proteins in the virus life cycle. Both MSH2 and MLH1 are required for efficient replication of HSV-1 in normal human cells and are localized to viral replication...

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PMID: 21957315
DOI: 10.1128/jvi.05487-11

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