Article

The immediate early protein 1 of human herpesvirus 6B counteracts ATM activation in an NBS1-dependent manner

2021-07-31

Abstract excerpt

Viral infection often trigger an ATM-dependent DNA damage response (DDR) in host cells that suppresses viral replication. To counteract this antiviral surveillance system, viruses evolved different strategies to induce the degradation of the MRE11/RAD50/NBS1 (MRN) complex and prevent subsequent DDR signaling. Here, we report that human herpesvirus 6B (HHV-6B) infection causes genomic instability by suppressing the...

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Literature Corpus work: 0a658e59-1304-57bc-bd16-14618c51340b
DOI: 10.1101/2021.07.31.454588

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